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| Cat.No | ACP12068 | Target Name | ZFYVE1 |
|---|---|---|---|
| Target Synonyms | ZFYVE1; DFCP1; KIAA1589; TAFF1; ZNFN2A1; PP10436Zinc finger FYVE domain-containing protein 1; Double FYVE-containing protein 1; SR3; Tandem FYVE fingers-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-777 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HBF4 |
|---|
Uniprot Id
Q9HBF4
Target Species
Human
Target Name
ZFYVE1
Target Full Name
Zinc finger FYVE domain-containing protein 1
Target Function
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. Regulates the morphology, size and distribution of LDs. Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger.
Target Subcellular Location
Golgi apparatus, Golgi stack. Golgi apparatus. Endoplasmic reticulum. Lipid droplet. Preautophagosomal structure. Mitochondrion.
Target Tissue Specificity
[Isoform 2]: Highly expressed in heart. Also detected in the testis.; [Isoform 1]: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart.
Target Synonyms
ZFYVE1; DFCP1; KIAA1589; TAFF1; ZNFN2A1; PP10436Zinc finger FYVE domain-containing protein 1; Double FYVE-containing protein 1; SR3; Tandem FYVE fingers-1
Target Background
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants.
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