Recombinant Human Zinc finger protein 207 (ZNF207)

Uniprot Id

O43670

Target Species

Human

Target Name

ZNF207

Target Full Name

BUB3-interacting and GLEBS motif-containing protein ZNF207

Target Function

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome.

Target Subcellular Location

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Zinc finger protein 207; ZN207_HUMAN; ZNF 207; ZNF207

Target Background

Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix.