Recombinant Human Zinc finger protein 385A (ZNF385A)

Uniprot Id

Q96PM9

Target Species

Human

Target Name

ZNF385A

Target Full Name

Zinc finger protein 385A

Target Function

RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation

Target Subcellular Location

Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite.

Target Tissue Specificity

Expressed predominantly in the retina.

Target Synonyms

DKFZP586G1122; Hematopoietic zinc finger protein; HZF; Retinal Zinc Finger; Retinal zinc finger protein; RZF; Z385A_HUMAN; ZFP385; Zinc Finger Protein 385; Zinc finger protein 385A; ZNF385; ZNF385A