Recombinant Human Zinc finger protein 451 (ZNF451), Truncated

Uniprot Id

Q9Y4E5

Target Species

Human

Target Name

ZNF451

Target Full Name

E3 SUMO-protein ligase ZNF451

Target Function

E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets

Target Subcellular Location

Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family

Target Synonyms

Coactivator for steroid receptors; COASTER; dJ417I1.1; E3 SUMO-protein ligase ZNF451; OTTHUMP00000218171; Zinc finger protein 451; ZN451_HUMAN; Znf451

Target Background

Enables SUMO ligase activity and transcription corepressor activity. Involved in negative regulation of nitrogen compound metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in nucleus.