Recombinant Human Zinc finger protein DPF3 (DPF3)

Uniprot Id

Q92784

Target Species

Human

Target Name

DPF3

Target Full Name

Zinc finger protein DPF3

Target Function

Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development

Target Subcellular Location

Nucleus.

Target Protein Families

Requiem/DPF family

Target Synonyms

2810403B03Rik; BAF45C; BRG1-associated factor 45C; cer-d4 homolog; CERD4; D4 zinc and double PHD fingers family member 3; D4; zinc and double PHD fingers; family 3; DPF 3; Dpf3; DPF3_HUMAN; FLJ 14079; FLJ14079; Mouse homolog of CER D4; Zinc finger protein cer-d4; Zinc finger protein DPF3