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| Cat.No | ACP08216 | Target Name | SLC39A4 |
|---|---|---|---|
| Target Synonyms | SLC39A4; ZIP4; Zinc transporter ZIP4; Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6P5W5 |
|---|
Uniprot Id
Q6P5W5
Target Species
Human
Target Name
SLC39A4
Target Full Name
Zinc transporter ZIP4
Target Function
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
Target Involvement
Acrodermatitis enteropathica, zinc-deficiency type (AEZ)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
Target Protein Families
ZIP transporter (TC 2.A.5) family
Target Tissue Specificity
Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.
Target Synonyms
SLC39A4; ZIP4; Zinc transporter ZIP4; Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4
Target Background
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene.
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