COMT Recombinant Monoclonal Antibody

Uniprot Id

P21964

Target Species

Human

Target Name

COMT

Target Full Name

Catechol O-methyltransferase

Target Function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Target Involvement

Schizophrenia (SCZD)

Target Subcellular Location

[Isoform Soluble]: Cytoplasm.; [Isoform Membrane-bound]: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family

Target Tissue Specificity

Brain, liver, placenta, lymphocytes and erythrocytes.

Target Research Area

Metabolism

Target Synonyms

Catechol O methyltransferase; Catechol O-methyltransferase; COMT; COMT_HUMAN; EC 2.1.1.6

Target Background

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.