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The antibody against Cytokeratin 8 was raised in Mouse using the synthetic Peptide of CK8 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Cytokeratin 8 was raised in Mouse using the synthetic Peptide of CK8 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using Cytokeratin 8 (10A5) Mouse mAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
| Cat.No | ADA-08330A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | Cytokeratin 8 |
| Target Synonyms | K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; Cytokeratin 8 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol, pH 7.3 | Purification Method | Affinity purification |
| Positive Samples | Mouse large intestine, Rat liver | Application | ELISA, WB |
| Immunogen Description | Synthetic Peptide of CK8 | Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. |
|---|---|---|---|
| Uniprot ID | P05787 |
Uniprot Id
P05787
Target Species
Human
Target Name
KRT8
Target Full Name
Keratin, type II cytoskeletal 8
Target Function
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Target Involvement
Cirrhosis (CIRRH)
Target Subcellular Location
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.
Target Protein Families
Intermediate filament family
Target Tissue Specificity
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Target Research Area
Immunology, Signal Transduction
Target Synonyms
CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; Cytokeratin-8; DreK8; EndoA; K2C8; K2C8_HUMAN; K8; Keratin 8; Keratin type II cytoskeletal 8 ; Keratin; type II cytoskeletal 8; Keratin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8
Target Background
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
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