Rabbit anti-Human Cytokeratin 2e (KRT2) Monoclonal Antibody

The antibody against Cytokeratin 2e (KRT2) was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 293-422 of humanKRT2(P35908) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-14434A

Number

Cat.No	ADA-14434A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Cytokeratin 2e (KRT2)
Target Synonyms	K2e; KRTE; CK-2e; KRT2A; KRT2E; Cytokeratin 2e (KRT2)	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-431	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-14434A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Cytokeratin 2e (KRT2)

Target Synonyms

K2e; KRTE; CK-2e; KRT2A; KRT2E; Cytokeratin 2e (KRT2)

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-431

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 293-422 of humanKRT2(P35908).	Target Species	Human
Immunogen Sequence	YMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQD	Uniprot ID	P35908

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 293-422 of humanKRT2(P35908).

Target Species

Human

Immunogen Sequence

YMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQD

Uniprot ID

P35908

Background Information

Uniprot Id

P35908
Target Species

Human
Target Name

KRT2
Target Full Name

Keratin, type II cytoskeletal 2 epidermal
Target Function

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin.
Target Involvement

Ichthyosis bullosa of Siemens (IBS)
Target Protein Families

Intermediate filament family
Target Tissue Specificity

Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expressi
Target Research Area

Others
Target Synonyms

KRT2; KRT2A; KRT2E; Keratin; type II cytoskeletal 2 epidermal; Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2
Target Background

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Rabbit anti-Human Cytokeratin 2e (KRT2) Monoclonal Antibody

Specifications

Immunogen Information

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