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Rabbit anti-Human Hex Monoclonal Antibody

The antibody against Hex was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 50-150 of human Hex (Q03014) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-16231A

The antibody against Hex was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 50-150 of human Hex (Q03014) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-16231A ClonalityMonoclonal
Host SpeciesRabbitTarget NameHex
Target SynonymsHEX; PRH; HMPH; PRHX; HOX11L-PEN; HexFormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesHep G2ApplicationELISA, WB

Immunogen Information


Immunogen DescriptionA synthetic peptide corresponding to a sequence within amino acids 50-150 of human Hex (Q03014).Target SpeciesHuman
Immunogen SequenceTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIUniprot IDQ03014
Background Information
  • Uniprot Id

    Q03014

  • Target Species

    Human

  • Target Name

    HHEX

  • Target Full Name

    Hematopoietically-expressed homeobox protein HHEX

  • Target Function

    Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. May play a role in hematopoietic differentiation.

  • Target Subcellular Location

    Nucleus.

  • Target Tissue Specificity

    Liver and promyelocytic leukemia cell line HL-60.

  • Target Synonyms

    HEX; PRH; HMPH; PRHX; HOX11L-PEN; Hex

  • Target Background

    This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.

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