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The antibody against TAPP1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 300-404 of human TAPP1 (Q9HB21) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TAPP1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 300-404 of human TAPP1 (Q9HB21) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using TAPP1 antibody at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
| Cat.No | ADA-13378A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TAPP1 |
| Target Synonyms | TAPP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Rat brain, A-549, HepG2, Jurkat, Mouse brain, Mouse lung | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 300-404 of human TAPP1 (Q9HB21). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | SEHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV | Uniprot ID | Q9HB21 |
Uniprot Id
Q9HB21
Target Species
Human
Target Name
PLEKHA1
Target Full Name
Pleckstrin homology domain-containing family A member 1
Target Function
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Target Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.
Target Tissue Specificity
Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.
Target Synonyms
OTTHUMP00000020651; PH domain containing family A member 1; PH domain-containing family A member 1; PKHA1_HUMAN; Pleckstrin homology domain containing A1; Pleckstrin homology domain containing family A member 1; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member; Pleckstrin homology domain-containing family A member 1; PLEKHA1; Tandem PH domain containing protein 1; Tandem PH domain-containing protein 1; TAPP 1; TAPP-1; TAPP1
Target Background
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3, 4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
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