Rabbit anti-Human Gelsolin Monoclonal Antibody

The antibody against Gelsolin was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 400-500 of human Gelsolin (NP_000168.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-14134A

Number

Cat.No	ADA-14134A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Gelsolin
Target Synonyms	ADF; AGEL; Gelsolin	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, A-549, C2C12, Mouse lung, RD	Application	ELISA, WB, IHC-P

Cat.No

ADA-14134A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Gelsolin

Target Synonyms

ADF; AGEL; Gelsolin

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, A-549, C2C12, Mouse lung, RD

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 400-500 of human Gelsolin (NP_000168.1).	Target Species	Human
Immunogen Sequence	DQTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQ	Uniprot ID	P06396

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 400-500 of human Gelsolin (NP_000168.1).

Target Species

Human

Immunogen Sequence

DQTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQ

Uniprot ID

P06396

Background Information

Uniprot Id

P06396
Target Species

Human
Target Name

GSN
Target Full Name

Gelsolin
Target Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Target Involvement

Amyloidosis 5 (AMYL5)
Target Subcellular Location

[Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted.
Target Protein Families

Villin/gelsolin family
Target Tissue Specificity

Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Target Research Area

Signal Transduction
Target Synonyms

Actin depolymerizing factor; Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS_HUMAN; Gelsolin; Gsn
Target Background

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.

Rabbit anti-Human Gelsolin Monoclonal Antibody

Specifications

Immunogen Information

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