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The recombinant antibody against SAA1 was produced using a synthesized peptide derived from Human SAA1 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, FC.
The recombinant antibody against SAA1 was produced using a synthesized peptide derived from Human SAA1 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, FC.
$350.00
| Cat.No | ADC-56564A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | SAA1 | Target Synonyms | SAA1, Serum amyloid A-1 protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA), Serum amyloid protein A(2-102), Serum amyloid protein A(2-103), Serum amyloid protein A(2-104), Serum amyloid protein A(3-104), Serum amyloid protein A(4-101)] |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, FC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from Human SAA1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P0DJI8 |
Uniprot Id
P0DJI8
Target Species
Human
Target Name
SAA1
Target Full Name
Serum amyloid A-1 protein
Target Function
Major acute phase protein.
Target Involvement
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Target Subcellular Location
Secreted.
Target Protein Families
SAA family
Target Tissue Specificity
Expressed by the liver; secreted in plasma (at protein level).
Target Synonyms
SAA; PIG4; SAA2; TP53I4; SAA1
Target Background
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
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