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The recombinant antibody against FGF19 was produced using a synthesized peptide derived from human FGF19 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
The recombinant antibody against FGF19 was produced using a synthesized peptide derived from human FGF19 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
$350.00
Western Blot | Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate | All lanes: FGF19 antibody at 1:500 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 25 kDa | Observed band size: 36 kDa
| Cat.No | ADC-56666A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | FGF19 | Target Synonyms | FGF19, Fibroblast growth factor 19 (FGF-19) |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human FGF19 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95750 |
Uniprot Id
O95750
Target Species
Human
Target Name
FGF19
Target Full Name
Fibroblast growth factor 19
Target Function
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Target Subcellular Location
Secreted.
Target Protein Families
Heparin-binding growth factors family
Target Tissue Specificity
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Target Research Area
Signal Transduction
Target Synonyms
FGF 19; FGF-19; FGF15; FGF19; FGF19_HUMAN; Fibroblast growth factor 15; Fibroblast growth factor 19
Target Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
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