Rabbit anti-Human Calpain small subunit 1 Monoclonal Antibody

Uniprot Id

P04632

Target Species

Human

Target Name

CAPNS1

Target Full Name

Calpain small subunit 1

Target Function

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Target Subcellular Location

Cytoplasm. Cell membrane.

Target Research Area

Signal Transduction

Target Synonyms

30K; Calcium activated neutral proteinase; Calcium activated neutral proteinase small subunit; Calcium dependent protease small subunit 1; Calcium dependent protease small subunit; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; Calpain 4; Calpain 4 small subunit (30K); Calpain 4 small subunit; Calpain regulatory subunit; Calpain S1; Calpain small polypeptide; Calpain small subunit 1; Calpain4; CalpainS1; CANP; CANP small subunit; CANPS; CAPN 4; CAPN S1; CAPN4; CAPNS 1; CAPNS; Capns1; CDPS; CPNS1_HUMAN; CSS 1; CSS1

Target Background

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.