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The antibody against GDF-8/Myostatin was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-375 of human GDF-8/Myostatin(NP_005250.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GDF-8/Myostatin was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-375 of human GDF-8/Myostatin(NP_005250.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-16376A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GDF-8/Myostatin |
| Target Synonyms | GDF8; MSLHP; GDF-8/Myostatin | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse skeletal muscle, Rat skeletal muscle | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 24-375 of human GDF-8/Myostatin(NP_005250.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O14793 | Immunogen Sequence |
Uniprot Id
O14793
Target Species
Human
Target Name
MSTN
Target Full Name
Growth/differentiation factor 8
Target Function
Acts specifically as a negative regulator of skeletal muscle growth.
Target Involvement
Muscle hypertrophy (MSLHP)
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Research Area
Signal Transduction
Target Synonyms
Cmpt; GDF-8; GDF8_HUMAN; Growth/differentiation factor 8; MSLHP; MSTN; MSTN myostatin; Myostatin; Myostatin Propeptide
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.
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