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The antibody against IFNLR1 was raised in mouse using the Recombinant IFNLR1 protein (21-228AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG2a, purified by protein A with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against IFNLR1 was raised in mouse using the Recombinant IFNLR1 protein (21-228AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG2a, purified by protein A with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$350.00
| Cat.No | ADC-56066A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | ifnlr1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG2a | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein A purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant IFNLR1 protein (21-228AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IU57 |
Uniprot Id
Q8IU57
Target Species
Human
Target Name
IFNLR1
Target Full Name
Interferon lambda receptor 1
Target Function
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Type II cytokine receptor family
Target Tissue Specificity
Widely expressed.
Target Research Area
Immunology
Target Synonyms
IFNLR1; IL28RA; LICR2; Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2
Target Background
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
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