Rabbit anti-Human Lamin B2 Monoclonal Antibody

The antibody against Lamin B2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 521-620 of human Lamin B2 (Q03252) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-16090A

Number

Cat.No	ADA-16090A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Lamin B2
Target Synonyms	EPM9; LMN2; LAMB2; MCPH27; Lamin B2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Jurkat, RD	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-16090A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Lamin B2

Target Synonyms

EPM9; LMN2; LAMB2; MCPH27; Lamin B2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Jurkat, RD

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 521-620 of human Lamin B2 (Q03252).	Target Species	Human
Immunogen Sequence	YILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM	Uniprot ID	Q03252

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 521-620 of human Lamin B2 (Q03252).

Target Species

Human

Immunogen Sequence

YILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM

Uniprot ID

Q03252

Background Information

Uniprot Id

Q03252
Target Species

Human
Target Name

LMNB2
Target Full Name

Lamin-B2
Target Function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Target Involvement

Partial acquired lipodystrophy (APLD); Epilepsy, progressive myoclonic 9 (EPM9)
Target Subcellular Location

Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
Target Protein Families

Intermediate filament family
Target Synonyms

EPM9; LMN2; LAMB2; MCPH27; Lamin B2
Target Background

This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.

Rabbit anti-Human Lamin B2 Monoclonal Antibody

Specifications

Immunogen Information

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