Rabbit anti-Human LI Cadherin/Cadherin-17 Monoclonal Antibody

Uniprot Id

Q12864

Target Species

Human

Target Name

CDH17

Target Full Name

Cadherin-17

Target Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.

Target Synonyms

BILL-cadherin; CAD17_HUMAN; Cadherin 16; Cadherin 16; formerly; Cadherin 17; cadherin 17; LI cadherin (liver-intestine); cadherin; liver-intestine; Cadherin-17; CDH16; CDH16; formerly; Cdh17; FLJ26931 ; Formerly Cadherin 16; Formerly CDH16; HPT 1; HPT-1 cadherin; human intestinal peptide-associated transporter HPT-1; human peptide transporter 1; Intestinal peptide-associated transporter HPT 1; Intestinal peptide-associated transporter HPT-1; LI-cadherin; Liver Cadherin; liver intestine cadherin; Liver-intestine cadherin

Target Background

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.