Rabbit anti-Human LOXL1 Monoclonal Antibody

Uniprot Id

Q08397

Target Species

Human

Target Name

LOXL1

Target Full Name

Lysyl oxidase homolog 1

Target Function

Active on elastin and collagen substrates.

Target Involvement

Exfoliation syndrome (XFS)

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Lysyl oxidase family

Target Tissue Specificity

Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina.

Target Research Area

Cell Biology, Metabolism

Target Synonyms

LOXL1; LOXLLysyl oxidase homolog 1; EC 1.4.3.-; Lysyl oxidase-like protein 1; LOL

Target Background

This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.