Rabbit anti-Human LSD2/KDM1B/AOF1 Monoclonal Antibody

The antibody against LSD2/KDM1B/AOF1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human LSD2/KDM1B/AOF1 (NP_694587.3) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-16244A

Number

Cat.No	ADA-16244A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	LSD2/KDM1B/AOF1
Target Synonyms	AOF1; LSD2; C6orf193; LSD2/KDM1B/AOF1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, HCT 116, HepG2	Application	ELISA, WB

Cat.No

ADA-16244A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

LSD2/KDM1B/AOF1

Target Synonyms

AOF1; LSD2; C6orf193; LSD2/KDM1B/AOF1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, HCT 116, HepG2

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LSD2/KDM1B/AOF1 (NP_694587.3).	Target Species	Human
Immunogen Sequence	MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTATCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYY	Uniprot ID	Q8NB78

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LSD2/KDM1B/AOF1 (NP_694587.3).

Target Species

Human

Immunogen Sequence

MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTATCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYY

Uniprot ID

Q8NB78

Background Information

Uniprot Id

Q8NB78
Target Species

Human
Target Name

KDM1B
Target Full Name

Lysine-specific histone demethylase 2
Target Function

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
Target Subcellular Location

Nucleus.
Target Protein Families

Flavin monoamine oxidase family
Target Synonyms

amine oxidase (flavin containing) domain 1 ; amine oxidase, flavin containing 1; AOF1; bA204B7.3; C6orf193; dJ298J15.2; Flavin-containing amine oxidase domain-containing protein 1; FLJ33898; FLJ34109; FLJ43328; KDM1B; KDM1B_HUMAN; LSD2; lysine (K)-specific demethylase 1B ; Lysine-specific demethylase 2; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
Target Background

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).

Rabbit anti-Human LSD2/KDM1B/AOF1 Monoclonal Antibody

Specifications

Immunogen Information

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