Rabbit anti-Human MMP7 Monoclonal Antibody

Uniprot Id

P09237

Target Species

Human

Target Name

MMP7

Target Full Name

Matrilysin

Target Function

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Peptidase M10A family

Target Research Area

Developmental Biology

Target Synonyms

Matrilysin; Matrin; Matrix Metalloproteinase 7; Matrix metalloproteinase-7; MMP 7; MMP-7; MMP7; MMP7_HUMAN; MPSL1; PUMP 1; Pump 1 protease; Pump-1 protease; PUMP1; Uterine matrilysin; Uterine metalloproteinase

Target Background

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.