Rabbit anti-Human SAE1 Monoclonal Antibody

The antibody against SAE1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 200-300 of human SAE1 (Q9UBE0) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-14114A

Number

Cat.No	ADA-14114A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	SAE1
Target Synonyms	AOS1; SUA1; UBLE1A; HSPC140; SAE1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, DU145, MCF7, Mouse testis	Application	ELISA, WB

Cat.No

ADA-14114A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

SAE1

Target Synonyms

AOS1; SUA1; UBLE1A; HSPC140; SAE1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, DU145, MCF7, Mouse testis

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SAE1 (Q9UBE0).	Target Species	Human
Immunogen Sequence	DSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA	Uniprot ID	Q9UBE0

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SAE1 (Q9UBE0).

Target Species

Human

Immunogen Sequence

DSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA

Uniprot ID

Q9UBE0

Background Information

Uniprot Id

Q9UBE0
Target Species

Human
Target Name

SAE1
Target Full Name

SUMO-activating enzyme subunit 1
Target Function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Target Subcellular Location

Nucleus.
Target Protein Families

Ubiquitin-activating E1 family
Target Tissue Specificity

Expression level increases during S phase and drops in G2 phase (at protein level).
Target Research Area

Cell Biology
Target Synonyms

Activator of SUMO1; AOS1; HSPC140; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS1; SUA1; SUMO 1 activating enzyme E1 N subunit; SUMO 1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; Ubiquitin like protein SUMO1 activating enzyme; Ubiquitin-like 1-activating enzyme E1A; UBL E1A; UBLE1A
Target Background

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).

Rabbit anti-Human SAE1 Monoclonal Antibody

Specifications

Immunogen Information

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