Rabbit anti-Human WAPL Monoclonal Antibody

The antibody against WAPL was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human WAPL (Q7Z5K2) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-14328A

Number

Cat.No	ADA-14328A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	WAPL
Target Synonyms	FOE; WAPAL; KIAA0261; WAPL	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, C2C12, Jurkat, RD	Application	ELISA, WB, IF/ICC

Cat.No

ADA-14328A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

WAPL

Target Synonyms

FOE; WAPAL; KIAA0261; WAPL

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, C2C12, Jurkat, RD

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human WAPL (Q7Z5K2).	Target Species	Human
Immunogen Sequence	MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSES	Uniprot ID	Q7Z5K2

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human WAPL (Q7Z5K2).

Target Species

Human

Immunogen Sequence

MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSES

Uniprot ID

Q7Z5K2

Background Information

Uniprot Id

Q7Z5K2
Target Species

Human
Target Name

WAPL
Target Full Name

Wings apart-like protein homolog
Target Function

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Target Subcellular Location

[Isoform 2]: Nucleus.; Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
Target Protein Families

WAPL family
Target Tissue Specificity

Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
Target Synonyms

FOE; Friend of EBNA2 (Epstein Barr virus nuclear protein 2); Friend of EBNA2 protein; KIAA0261; OTTHUMP00000020004; WAPAL; WAPL; WAPL_HUMAN; Wings apart like homolog; Wings apart like homolog (Drosophila); Wings apart-like protein homolog
Target Background

Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule cytoskeleton.

Rabbit anti-Human WAPL Monoclonal Antibody

Specifications

Immunogen Information

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