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The recombinant antibody against IL2RA was produced using the Recombinant Human IL2RA protein as the immunogen. This antibody exists as a non-conjugated isotype hIgG1, Affinity-chromatography purified. This antibody has been validated on ELISA, IF.
The recombinant antibody against IL2RA was produced using the Recombinant Human IL2RA protein as the immunogen. This antibody exists as a non-conjugated isotype hIgG1, Affinity-chromatography purified. This antibody has been validated on ELISA, IF.
$350.00
Immunofluorescence staining of Hela cell with IL2RA Recombinant Monoclonal Antibody at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).2
| Cat.No | ADC-56435A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | IL2RA | Form | Liquid |
| Species Reactivity | Human | Isotype | hIgG1 |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Affinity-chromatography purified |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human IL2RA protein | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P01589 |
Uniprot Id
P01589
Target Species
Human
Target Name
IL2RA
Target Full Name
Interleukin-2 receptor subunit alpha
Target Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Target Involvement
Diabetes mellitus, insulin-dependent, 10 (IDDM10); Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Research Area
Cancer
Target Synonyms
IL2RA; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; CD antigen CD25
Target Background
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
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