ITGAL Recombinant Monoclonal Antibody

Uniprot Id

P20701

Target Species

Human

Target Name

ITGAL

Target Full Name

Integrin alpha-L

Target Function

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Integrin alpha chain family

Target Tissue Specificity

Leukocytes.

Target Research Area

Immunology

Target Synonyms

Antigen CD11A (p180); lymphocyte function associated antigen 1; alpha polypeptide; CD11 antigen-like family member A; CD11a; CD18; CR3; Integrin alpha-L; Integrin beta 2 ; Integrin gene promoter; ITAL_HUMAN; Itgal; ITGAM; ITGB2; LAD; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA 1 alpha; LFA 1; LFA-1A; LFA1; LFA1A; Lymphocyte function associated antigen 1; MAC1; MFI7; MO1A

Target Background

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.