KRT20 Recombinant Monoclonal Antibody

Uniprot Id

P35900

Target Species

Human

Target Name

KRT20

Target Full Name

Keratin, type I cytoskeletal 20

Target Function

Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Intermediate filament family

Target Tissue Specificity

Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of t

Target Synonyms

CD20; CK 20 ; CK-20; CK20; Cytokeratin-20; Cytokeratin20 ; K1C20_HUMAN; K20; KA20; Keratin 20; keratin 20, type I; keratin 21, rat, homolog of; Keratin; Keratin type I cytoskeletal 20 ; Keratin-20; Keratin20; KRT 20; KRT 21; KRT20; KRT21 ; MGC35423; OTTHUMP00000164518; Protein IT; type I cytoskeletal 20

Target Background

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.