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The recombinant antibody against PDE4D was produced using a synthesized peptide derived from human PDE4D as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
The recombinant antibody against PDE4D was produced using a synthesized peptide derived from human PDE4D as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
$350.00
Western Blot | Positive WB detected in: THP-1 whole cell lysate | All lanes: PDE4D antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 92, 77, 69, 67, 58, 85, 24, 60, 78, 77, 85, 25 kDa | Observed band size: 92 kDa
| Cat.No | ADC-56834A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | PDE4D | Target Synonyms | 5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43), cAMP specific 3', DPDE3, PDE4D |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human PDE4D | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q08499 |
Uniprot Id
Q08499
Target Species
Human
Target Name
PDE4D
Target Full Name
3',5'-cyclic-AMP phosphodiesterase 4D
Target Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Target Involvement
Acrodysostosis 2, with or without hormone resistance (ACRDYS2)
Target Subcellular Location
Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
Target Tissue Specificity
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Target Synonyms
DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; PDE4D
Target Background
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3', 5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
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