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The recombinant antibody against DEK was produced using a synthesized peptide derived from Human DEK as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC, IF, FC.
The recombinant antibody against DEK was produced using a synthesized peptide derived from Human DEK as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC, IF, FC.
$350.00
| Cat.No | ADC-56476A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | DEK | Target Synonyms | DEK, Protein DEK |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, FC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from Human DEK | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P35659 |
Uniprot Id
P35659
Target Species
Human
Target Name
DEK
Target Full Name
Protein DEK
Target Function
Involved in chromatin organization.
Target Involvement
A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
Target Subcellular Location
Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Target Tissue Specificity
Ubiquitous. Expressed at relatively high levels.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
D6S231E; Dek; DEK gene; DEK oncogene; DEK oncogene DNA binding; DEK_HUMAN; Protein DEK
Target Background
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
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