Rabbit anti-Human Neuropilin-2/NRP2 Monoclonal Antibody

Uniprot Id

O60462

Target Species

Human

Target Name

NRP2

Target Full Name

Neuropilin-2

Target Function

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.; (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.; [Isoform s9]: Secreted.

Target Protein Families

Neuropilin family

Target Synonyms

MGC126574; Neuropilin 2; Neuropilin-2; Neuropilin2; NP 2; NP2 ; NPN 2; NPN2; NRP 2; Nrp2; NRP2_HUMAN; PRO2714 ; Receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; Vascular endothelial growth factor 165 receptor 2; VEGF1265R2; VEGF165R2

Target Background

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells.