Rabbit anti-Human NgR3 Monoclonal Antibody

The antibody against NgR3 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 342-441 of human NgR3 (Q86UN2) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-13330A

Number

Cat.No	ADA-13330A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	NgR3
Target Synonyms	NgR3; NGRH2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, Mouse brain, SH-SY5Y, T47D	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-13330A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

NgR3

Target Synonyms

NgR3; NGRH2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, Mouse brain, SH-SY5Y, T47D

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 342-441 of human NgR3 (Q86UN2).	Target Species	Human
Immunogen Sequence	PHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVTLR	Uniprot ID	Q86UN2

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 342-441 of human NgR3 (Q86UN2).

Target Species

Human

Immunogen Sequence

PHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVTLR

Uniprot ID

Q86UN2

Background Information

Uniprot Id

Q86UN2
Target Species

Human
Target Name

RTN4RL1
Target Full Name

Reticulon-4 receptor-like 1
Target Function

Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Perikaryon. Cell projection.
Target Protein Families

Nogo receptor family
Target Tissue Specificity

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
Target Synonyms

DKFZp547J144; NgR 3; NgR3; NGRH 2; NGRH2; NGRL2; Nogo 66 receptor homolog 2; Nogo 66 receptor related protein 3; Nogo receptor like 2; Nogo receptor-like 2; Nogo-66 receptor homolog 2; Nogo-66 receptor-related protein 3; R4RL1_HUMAN; Reticulon 4 receptor like 1; Reticulon-4 receptor-like 1; RTN4RL1
Target Background

Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface. Is anchored component of plasma membrane.

Rabbit anti-Human NgR3 Monoclonal Antibody

Specifications

Immunogen Information

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