Rabbit anti-Human Phospho-Acetyl CoA Carboxylase 1-S79 Monoclonal Antibody

Uniprot Id

Q13085

Target Species

Human

Target Name

ACACA

Target Full Name

Acetyl-CoA carboxylase 1

Target Function

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.

Target Involvement

Acetyl-CoA carboxylase 1 deficiency (ACACAD)

Target Subcellular Location

Cytoplasm, cytosol.

Target Tissue Specificity

Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

Target Research Area

Cancer

Target Synonyms

ACAC; ACACA; ACACA_HUMAN; ACACB; ACC alpha; ACC; ACC beta ; ACC-alpha; ACC1; ACC2; ACCA; ACCB; Acetyl CoA carboxylase 1; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase alpha ; Acetyl CoA carboxylase beta; Acetyl Coenzyme A carboxylase alpha; Acetyl Coenzyme A carboxylase beta; Biotin carboxylase; COA1; COA2; HACC275; OTTHUMP00000164069; OTTHUMP00000164070; OTTHUMP00000164076; OTTHUMP00000240532

Target Background

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.