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The antibody against Phospho-Smad5-S465 was raised in Rabbit using a synthetic phosphorylated peptide around S465 of human Smad5 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Phospho-Smad5-S465 was raised in Rabbit using a synthetic phosphorylated peptide around S465 of human Smad5 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-15141A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Phospho-Smad5-S465 |
| Target Synonyms | DWFC; JV5-1; MADH5; Phospho-Smad5-S465 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | C6, NIH/3T3 | Application | ELISA, WB |
| Immunogen Description | A synthetic phosphorylated peptide around S465 of human Smad5. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99717 |
Uniprot Id
Q99717
Target Species
Human
Target Name
SMAD5
Target Full Name
Mothers against decapentaplegic homolog 5
Target Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
Target Subcellular Location
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
Target Protein Families
Dwarfin/SMAD family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
DKFZp781C1895; DKFZp781O1323; Dwfc; hSmad5; JV5 1; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; MADH 5; MADH5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against DPP homolog 5; MusMLP; SMA and MAD related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; Smad5; SMAD5_HUMAN
Target Background
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.
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