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The antibody against Phospho-SMO-S616 was raised in Rabbit using a synthetic phosphorylated peptide around S616 of human SMO (NP_005622.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA, DB.
The antibody against Phospho-SMO-S616 was raised in Rabbit using a synthetic phosphorylated peptide around S616 of human SMO (NP_005622.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA, DB.
Dot-blot analysis of all sorts of peptides using Phospho-SMO-S616 antibody at 1:1000 dilution.
Exposure time: 1s.
| Cat.No | ADA-07228A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Phospho-SMO-S616 |
| Target Synonyms | Gx; CRJS; PHLS; SMOH; FZD11; Phospho-SMO-S616 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, DB |
| Immunogen Description | A synthetic phosphorylated peptide around S616 of human SMO (NP_005622.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | VSSAW | Uniprot ID | Q99835 |
Uniprot Id
Q99835
Target Species
Human
Target Name
SMO
Target Full Name
Protein smoothened
Target Function
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
Target Involvement
Curry-Jones syndrome (CRJS)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cell projection, cilium.
Target Protein Families
G-protein coupled receptor Fz/Smo family
Target Synonyms
SMO; SMOH; Smoothened homolog; SMO; Protein Gx
Target Background
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
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