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The antibody against Prion Protein was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 154-253 of human Prion Protein (P04156) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Prion Protein was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 154-253 of human Prion Protein (P04156) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-13996A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Prion Protein |
| Target Synonyms | CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; Prion Protein | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 154-253 of human Prion Protein (P04156). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG | Uniprot ID | P04156 |
Uniprot Id
P04156
Target Species
Human
Target Name
PRNP
Target Full Name
Major prion protein
Target Function
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Target Involvement
Creutzfeldt-Jakob disease (CJD); Fatal familial insomnia (FFI); Gerstmann-Straussler disease (GSD); Huntington disease-like 1 (HDL1); Kuru (KURU); Spongiform encephalopathy with neuropsychiatric features (SENF)
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Target Protein Families
Prion family
Target Synonyms
CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; Prion Protein
Target Background
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
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