Rabbit anti-Human PDCD4 Monoclonal Antibody

The antibody against PDCD4 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 370-469 of human PDCD4 (Q53EL6) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-15818A

Number

Cat.No	ADA-15818A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	PDCD4
Target Synonyms	H731; PDCD4	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, Mouse liver, Mouse thymus, U-937	Application	ELISA, WB, IHC-P

Cat.No

ADA-15818A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

PDCD4

Target Synonyms

H731; PDCD4

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, Mouse liver, Mouse thymus, U-937

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 370-469 of human PDCD4 (Q53EL6).	Target Species	Human
Immunogen Sequence	MVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY	Uniprot ID	Q53EL6

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 370-469 of human PDCD4 (Q53EL6).

Target Species

Human

Immunogen Sequence

MVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY

Uniprot ID

Q53EL6

Background Information

Uniprot Id

Q53EL6
Target Species

Human
Target Name

PDCD4
Target Full Name

Programmed cell death protein 4
Target Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
Target Subcellular Location

Nucleus. Cytoplasm.
Target Protein Families

PDCD4 family
Target Tissue Specificity

Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Target Research Area

Cancer
Target Synonyms

Death up-regulated gene protein; Dug; H731; Ma3; MGC33046; MGC33047; Neoplastic transformation inhibitor; Neoplastic transformation inhibitor protein; Nuclear antigen H731; Nuclear antigen H731 like; Nuclear antigen H731 like protein; Nuclear antigen H731-like; PDCD 4; Pdcd4; PDCD4_HUMAN; Programmed cell death 4 ; programmed cell death 4 (neoplastic transformation inhibitor); Programmed cell death protein 4; Protein 197/15a; Protein MA-3; Tis; Topoisomerase-inhibitor suppressed protein
Target Background

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human PDCD4 Monoclonal Antibody

Specifications

Immunogen Information

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