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Rabbit anti-Human ATOH1 Monoclonal Antibody

The antibody against ATOH1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATOH1 (Q92858) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-16004A

The antibody against ATOH1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATOH1 (Q92858) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-16004A ClonalityMonoclonal
Host SpeciesRabbitTarget NameAtoh1
Target SynonymsATH1; HATH1; DFNA89; MATH-1; bHLHa14; ATOH1FormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesHeLa, A549, HCT116ApplicationELISA, WB

Immunogen Information


Immunogen DescriptionA synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATOH1 (Q92858).Target SpeciesHuman
Immunogen SequenceMSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDUniprot IDQ92858
Background Information
  • Uniprot Id

    Q92858

  • Target Species

    Human

  • Target Name

    ATOH1

  • Target Full Name

    Transcription factor ATOH1

  • Target Function

    Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

  • Target Subcellular Location

    Nucleus.

  • Target Research Area

    Epigenetics and Nuclear Signaling, Developmental Biology

  • Target Synonyms

    ATH1; ATOH1; ATOH1_HUMAN; Atonal homolog 1 (Drosophila); Atonal homolog 1; bHLHa14; Class A basic helix-loop-helix protein 14; hATH1; Helix loop helix protein hATH 1; Helix-loop-helix protein hATH-1; MATH 1; MATH1; Protein atonal homolog 1

  • Target Background

    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in neuron differentiation; positive regulation of neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including generation of neurons; inner ear morphogenesis; and positive regulation of inner ear auditory receptor cell differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus.

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