Rabbit anti-Human SLC7A11/xCT Monoclonal Antibody

The antibody against SLC7A11/xCT was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC7A11/xCT (Q9UPY5) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-17159A

Number

Cat.No	ADA-17159A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	SLC7A11/xCT
Target Synonyms	xCT; CCBR1; SLC7A11/xCT	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Rat brain, 293T, HepG2, Mouse liver, Rat liver	Application	ELISA, WB

Cat.No

ADA-17159A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

SLC7A11/xCT

Target Synonyms

xCT; CCBR1; SLC7A11/xCT

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Rat brain, 293T, HepG2, Mouse liver, Rat liver

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC7A11/xCT (Q9UPY5).	Target Species	Human
Immunogen Sequence	MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAEL	Uniprot ID	Q9UPY5

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC7A11/xCT (Q9UPY5).

Target Species

Human

Immunogen Sequence

MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAEL

Uniprot ID

Q9UPY5

Background Information

Uniprot Id

Q9UPY5
Target Species

Human
Target Name

SLC7A11
Target Full Name

Cystine/glutamate transporter
Target Function

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
Target Subcellular Location

Membrane; Multi-pass membrane protein.
Target Protein Families

Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Target Synonyms

SLC7A11; Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT
Target Background

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Rabbit anti-Human SLC7A11/xCT Monoclonal Antibody

Specifications

Immunogen Information

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