CLDN6/9 Recombinant Monoclonal Antibody

Uniprot Id

P56747

Target Species

Human

Target Name

CLDN6

Target Full Name

Claudin-6

Target Function

Plays a major role in tight junction-specific obliteration of the intercellular space.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

Target Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Claudin family

Target Tissue Specificity

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.

Target Synonyms

CLDN6; UNQ757/PRO1488; Claudin-6; Skullin

Target Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.