Rabbit anti-Human CD27 Monoclonal Antibody

The antibody against CD27 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD27 (P26842) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-16176A

Number

Cat.No	ADA-16176A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	CD27
Target Synonyms	T14; S152; Tp55; TNFRSF7; S152. LPFS2; CD27	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat thymus, THP-1	Application	ELISA, WB, IF/ICC

Cat.No

ADA-16176A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

CD27

Target Synonyms

T14; S152; Tp55; TNFRSF7; S152. LPFS2; CD27

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat thymus, THP-1

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD27 (P26842).	Target Species	Human
Immunogen Sequence	MARPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITA	Uniprot ID	P26842

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD27 (P26842).

Target Species

Human

Immunogen Sequence

MARPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITA

Uniprot ID

P26842

Background Information

Uniprot Id

P26842
Target Species

Human
Target Name

CD27
Target Full Name

CD27 antigen
Target Function

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Target Involvement

Lymphoproliferative syndrome 2 (LPFS2)
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Tissue Specificity

Found in most T-lymphocytes.
Target Synonyms

CD27; TNFRSF7; CD27 antigen; CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD antigen CD27
Target Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Rabbit anti-Human CD27 Monoclonal Antibody

Specifications

Immunogen Information

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