Rabbit anti-Human Glyt2 Monoclonal Antibody

Uniprot Id

Q9Y345

Target Species

Human

Target Name

SLC6A5

Target Full Name

Sodium- and chloride-dependent glycine transporter 2

Target Function

Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.

Target Involvement

Hyperekplexia 3 (HKPX3)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A5 subfamily

Target Tissue Specificity

Expressed in medulla, and to a lesser extent in spinal cord and cerebellum.

Target Synonyms

Glycine transporter; Glycine transporter type 2; GlyT-2; GlyT2; NET1; SC6A5_HUMAN; SC6AC5; Slc6a5; SLC6A5 solute carrier family 6 neurotransmitter transporter, glycine member 5; Slc6a9; Sodium and chloride dependent glycine transporter 2; Sodium- and chloride-dependent glycine transporter 2; Solute carrier family 6 member 5; Solute carrier family 6 neurotransmitter transporter glycine member 5

Target Background

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene.