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The antibody against ITPR3 was raised in Rabbit using the recombinant protein of human ITPR3 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ITPR3 was raised in Rabbit using the recombinant protein of human ITPR3 as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-16398A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ITPR3 |
| Target Synonyms | IP3R; CMT1J; IP3R3; ITPR3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HEL(Negative control), SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant protein of human ITPR3. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14573 |
Uniprot Id
Q14573
Target Species
Human
Target Name
ITPR3
Target Full Name
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
Target Function
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
InsP3 receptor family
Target Tissue Specificity
Expressed in intestinal crypt and villus epithelial cells.
Target Synonyms
4; 5-trisphosphate receptor; 5-trisphosphate receptor type 3; FLJ36205; Inositol 1; Inositol 1,4,5 trisphosphate receptor type 3; InsP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R; IP3R3; ITPR 3; ITPR3; ITPR3_HUMAN; Type 3 inositol 1; Type 3 inositol 1,4,5 trisphosphate receptor; Type 3 InsP3 receptor
Target Background
This gene encodes a receptor for inositol 1, 4, 5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1, 4, 5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
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