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The antibody against MMUT was raised in mouse using the Recombinant Human Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG1, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against MMUT was raised in mouse using the Recombinant Human Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG1, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western Blot Positive WB detected in: MMUT antibody at 1:1000 Lane 1: Mouse liver tissue Lane 2: Rat kidney tissue Lane 3: Rat heart tissue Secondary Goat polyclonal to Mouse IgG at 1/20000 dilution Predicted band size: 83 KDa Observed band size: 83 KDa Exposure time: 5min
Western Blot Positive WB detected in: MMUT antibody at 1:1000 Lane 1: U87 whole cell lysate Lane 2: U251 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: K562 whole cell lysate Lane 5: 293 whole cell lysate Secondary Goat polyclonal to Mouse IgG at 1/20000 dilution Predicted band size: 83 KDa Observed band size: 83 KDa Exposure time: 5min2
| Cat.No | ADC-56068A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | MMUT |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG1 | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P22033 |
Uniprot Id
P22033
Target Species
Human
Target Name
MMUT
Target Full Name
Methylmalonyl-CoA mutase, mitochondrial
Target Function
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
Target Involvement
Methylmalonic aciduria type mut (MMAM)
Target Subcellular Location
Mitochondrion matrix. Mitochondrion. Cytoplasm.
Target Protein Families
Methylmalonyl-CoA mutase family
Target Research Area
Signal Transduction
Target Synonyms
MCM; Methylmalonyl CoA isomerase ; Methylmalonyl CoA mutase mitochondrial; Methylmalonyl Coenzyme A mutase; Methylmalonyl-CoA isomerase; Methylmalonyl-CoA mutase; mitochondrial; Mut; MUTA_HUMAN
Target Background
This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria.
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