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The antibody against SMURF1 was raised in mouse using the Recombinant Human E3 ubiquitin-protein ligase SMURF1 protein (198-374AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG2a, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF, FC.
The antibody against SMURF1 was raised in mouse using the Recombinant Human E3 ubiquitin-protein ligase SMURF1 protein (198-374AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG2a, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF, FC.
$350.00
| Cat.No | ADC-56050A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | SMURF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG2a | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB, FC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase SMURF1 protein (198-374AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HCE7 |
Uniprot Id
Q9HCE7
Target Species
Human
Target Name
SMURF1
Target Full Name
E3 ubiquitin-protein ligase SMURF1
Target Function
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Plays a role in dendrite formation by melanocytes.
Target Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Target Tissue Specificity
Expressed in melanocytes.
Target Research Area
Cell Biology
Target Synonyms
E3 ubiquitin-protein ligase SMURF1; hSMURF1; KIAA1625; Smad specific E3 ubiquitin ligase 1; SMAD specific E3 ubiquitin protein ligase 1; Smad ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMUF1_HUMAN; SMURF 1; smurf1
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