NUDT5 Recombinant Monoclonal Antibody

Uniprot Id

Q9UKK9

Target Species

Human

Target Name

NUDT5

Target Full Name

ADP-sugar pyrophosphatase

Target Function

Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Target Subcellular Location

Nucleus.

Target Protein Families

Nudix hydrolase family

Target Tissue Specificity

Widely expressed. Most abundant in liver.

Target Synonyms

ADP sugar pyrophosphatase; ADP-sugar pyrophosphatase; hYSAH 1; hYSAH1; Nucleoside diphosphate linked moiety X motif 5; Nucleoside diphosphate linked moiety X type motif 5; Nucleoside diphosphate-linked moiety X motif 5; Nudix (nucleoside diphosphate linked moiety X) type motif 5; Nudix motif 5; Nudix type motif 5; NUDT 5; Nudt5; NUDT5_HUMAN; YSA1; YSA1H

Target Background

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors.