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The recombinant antibody against STAT4 was produced using a synthesized peptide derived from human STAT4 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC, IF.
The recombinant antibody against STAT4 was produced using a synthesized peptide derived from human STAT4 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC, IF.
$350.00
| Cat.No | ADC-56688A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | STAT4 | Target Synonyms | Signal transducer and activator of transcription 4, STAT4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human STAT4 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14765 |
Uniprot Id
Q14765
Target Species
Human
Target Name
STAT4
Target Full Name
Signal transducer and activator of transcription 4
Target Function
Carries out a dual signal transduction and activation of transcription. Involved in IL12 signaling.
Target Involvement
Systemic lupus erythematosus 11 (SLEB11); Rheumatoid arthritis (RA)
Target Subcellular Location
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Target Protein Families
Transcription factor STAT family
Target Synonyms
Signal transducer and activator of transcription 4; SLEB11; STAT4; STAT4_HUMAN
Target Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
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