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The antibody against HECW1 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase HECW1 protein (751-900AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against HECW1 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase HECW1 protein (751-900AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-00650A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HECW1 |
| Target Synonyms | C2 and WW domain containing E3 ubiquitin protein ligase 1 antibody; HECT, C2 and WW domain-containing protein 1 antibody; E3 ubiquitin-protein ligase HECW1 antibody; HECT antibody; HECT type E3 ubiquitin ligase antibody; HECT | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Antigen Affinity purified & Affinity purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase HECW1 protein (751-900AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q76N89 |
Uniprot Id
Q76N89
Target Species
Human
Target Name
HECW1
Target Full Name
E3 ubiquitin-protein ligase HECW1
Target Function
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
Target Synonyms
C2 and WW domain-containing protein 1; E3 ubiquitin-protein ligase HECW1; HECT; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; HECT, C2 and WW domain-containing protein 1; HECW 1; Hecw1; HECW1_HUMAN; hNEDL1; NEDD4 like ubiquitin protein ligase 1; NEDD4-like E3 ubiquitin-protein ligase 1; NEDL1
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