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The antibody against EARS2 was raised in rabbit using the Recombinant Human Probable glutamate--tRNA ligase, mitochondrial protein (42-166AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against EARS2 was raised in rabbit using the Recombinant Human Probable glutamate–tRNA ligase, mitochondrial protein (42-166AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human ovarian cancer using EARS2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using EARS2 Antibody at dilution of 1:1002
| Cat.No | ADC-10371A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EARS2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Probable glutamate--tRNA ligase, mitochondrial protein (42-166AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q5JPH6 |
Uniprot Id
Q5JPH6
Target Species
Human
Target Name
EARS2
Target Full Name
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial
Target Function
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Target Involvement
Combined oxidative phosphorylation deficiency 12 (COXPD12)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Class-I aminoacyl-tRNA synthetase family, Glutamate--tRNA ligase type 1 subfamily
Target Synonyms
3230401I01Rik; AL024049; COXPD12; EARS 2; ears2; GluRS; Glutamate--tRNA ligase; Glutamyl tRNA synthetase 2 mitochondrial; KIAA1970; mitochondrial; mKIAA1970; MSE1; Probable glutamyl tRNA synthetase; mitochondrial ; Probable glutamyl-tRNA synthetase; RGD1307904; SYEM_HUMAN
Target Background
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants.
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