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The antibody against AICDA was raised in rabbit using the Recombinant Human Single-stranded DNA cytosine deaminase protein (1-60AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against AICDA was raised in rabbit using the Recombinant Human Single-stranded DNA cytosine deaminase protein (1-60AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-16133A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AICDA |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Single-stranded DNA cytosine deaminase protein (1-60AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9GZX7 |
Uniprot Id
Q9GZX7
Target Species
Human
Target Name
AICDA
Target Full Name
Single-stranded DNA cytosine deaminase
Target Function
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Target Involvement
Immunodeficiency with hyper-IgM 2 (HIGM2)
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
Cytidine and deoxycytidylate deaminase family
Target Tissue Specificity
Strongly expressed in lymph nodes and tonsils.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Activation induced cytidine deaminase; Activation induced deaminase; Activation-induced cytidine deaminase; AICDA; AICDA_HUMAN; AID; ARP 2; ARP2; CDA 2; CDA2; Cytidine aminohydrolase; HIGM2; Integrated into Burkitt's lymphoma cell line Ramos
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