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The antibody against HOMER2 was raised in rabbit using the Recombinant Human Homer protein homolog 2 protein (1-343AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against HOMER2 was raised in rabbit using the Recombinant Human Homer protein homolog 2 protein (1-343AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using HOMER2 Antibody at dilution of 1:100
| Cat.No | ADC-24725A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HOMER2 |
| Target Synonyms | HOMER2 antibody; Homer protein homolog 2 antibody; Homer-2 antibody; Cupidin antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Homer protein homolog 2 protein (1-343AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NSB8 |
Uniprot Id
Q9NSB8
Target Species
Human
Target Name
HOMER2
Target Full Name
Homer protein homolog 2
Target Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Target Involvement
Deafness, autosomal dominant, 68 (DFNA68)
Target Subcellular Location
Cytoplasm. Cell membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Target Protein Families
Homer family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
HOMER2; Homer protein homolog 2; Homer-2; Cupidin
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